CAS 2627-69-2 Pharmaceutical Intermediate 98% Aicar White Powder
Quick Detail:
Product Name: AICAR/ Acadesine
Full name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
Alias: AICA Riboside; Acadesine
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Appearance: White powder
Purity: 99%
Usage: Glucose uptake stimulant; AMPK activator; AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Payment method: Western Union, Money Gram, T/T.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3days after payment, 7-10days to arrive.
Description:
Aicar is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.
Aicar is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
Aicar can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
Application:
Aicar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR& alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.
Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
COA:
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Related substance (HPLC) | Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
| Odor | Characteristic | Complies |
| Assay | 99% | 99.8% |
| Sieve analysis | 100% pass 80 mesh | Complies |
| Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
| Heavy Metal | <10ppm | Complies |
| As | <0.1ppm | 0.05ppm |
| Pb | <0.1ppm | 0.05ppm |
| Cd | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Residual Pesticide | Negative | Complies |
| Microbiology | Â | Â |
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Mold | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
Our adwantage:
1, High quality with competitive price:
  1) Standard: Enterprise Standard
  2) All Purity≥98%
  3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
  1) Parcel can be sent out within 24 hours after payment. Tracking number available
  2) Secure and discreet shipment. Various transportation methods for your choice.
  3) Customs pass rate ≥99%
  4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and    we have stock in there for transferring.
3, We have clients throughout the world.
  1) Professional service and rich experience make customers feel at ease, adequate stock and fast         delivery meet their desire.
  2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our       responsibility.
  3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the         customers.
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CAS 2627-69-2 Pharmaceutical Intermediate 98% Aicar White Powder
Quick Detail:
Product Name: AICAR/ Acadesine
Full name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
Alias: AICA Riboside; Acadesine
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Appearance: White powder
Purity: 99%
Usage: Glucose uptake stimulant; AMPK activator; AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Payment method: Western Union, Money Gram, T/T.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3days after payment, 7-10days to arrive.
Description:
Aicar is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.
Aicar is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
Aicar can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
Application:
Aicar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR& alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.
Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
COA:
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Related substance (HPLC) | Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
| Odor | Characteristic | Complies |
| Assay | 99% | 99.8% |
| Sieve analysis | 100% pass 80 mesh | Complies |
| Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
| Heavy Metal | <10ppm | Complies |
| As | <0.1ppm | 0.05ppm |
| Pb | <0.1ppm | 0.05ppm |
| Cd | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Residual Pesticide | Negative | Complies |
| Microbiology | Â | Â |
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Mold | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
Our adwantage:
1, High quality with competitive price:
  1) Standard: Enterprise Standard
  2) All Purity≥98%
  3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
  1) Parcel can be sent out within 24 hours after payment. Tracking number available
  2) Secure and discreet shipment. Various transportation methods for your choice.
  3) Customs pass rate ≥99%
  4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and    we have stock in there for transferring.
3, We have clients throughout the world.
  1) Professional service and rich experience make customers feel at ease, adequate stock and fast         delivery meet their desire.
  2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our       responsibility.
  3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the         customers.
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We have many kinds of sanitary pads at your choice, and we could produce according to your requirement.
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