Quick Detail:Â
Product Name: Mirtazapine
CAS NO.: 85650-52-8
Molecular Formula: C17H19N3
Molecular Weight: 265.35
Purity: 99%
Appearance: White Powder
Grade: Pharmaceutical Grade
Description:
Mirtazapine, is an atypical antidepressant with noradrenergic and specific serotonergic activity. It blocks the α2 adrenergic auto- and heteroreceptors (enhancing norepinephrine release), and selectively antagonizes the 5-HT2 serotonin receptors in the central and peripheral nervous system. It also enhances serotonin neurotransmission at the 5-HT1 receptor and blocks the histaminergic (H1) and muscarinic receptors. Mirtazapine is not a serotonin or norepinephrine reuptake inhibitor but may increase serotonin and norepinephrine by other mechanisms of action.
Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA),and is used primarily in the treatment of depression. It is also commonly used as an anxiolytic, hypnotic, antiemetic and appetite stimulant. In structure, mirtazapine can also be classified as a tetracyclic antidepressant (TeCA) and is the 6-aza analogue of mianserin.It is also racemic - occurs as a combination of both (R)-(−)- and (S)-(+)-stereoisomers, both of which are active.
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Dosage:
Oral, can swallow with water, do not chew. The initial dose of adult treatment is 15mg (1/2 tablet) once daily, and then gradually increase the dose for optimal efficacy. The effective oral dose is usually 15-45mg (1/2 tablet-1.5 tablet) per day. Patients with liver and kidney damage, mirtazapine clearance decreased, so these patients medication should be noted. The half-life of mirtazapine is 20-40 hours, so medication can be done once a day, before going to bed to take effect better. Can also be sub-service, sooner or later each time. Patients should continue to take medicine, preferably in the symptoms disappear completely 4-6 months after withdrawal. Appropriate doses within 2-4 weeks will have a significant effect. If the effect is not obvious, the dose can be increased until the maximum dose, such as 2-4 weeks after the dose was still no significant effect, should immediately stop the medication .
COA:
Items | Standard | Â Â Â Result |
    Appearance | White or off-white powder | Complies |
Identification |
The IR absorption spectrum is accordant with the spectrum obtained with CRS |
Complies |
 Solubility | , Practically insoluble in water,freely soluble in anhydrous ethanol |
Complies |
specific rotation |
-0.10°~+0.10° (anhydrous substance) |
+0.001° |
Water | ≤3.5% | 2.8% |
Sulfated ash | ≤0.10% | 0.04% |
granularity | 80%<75 m | 39.28 m |
Residual solvents | Ethanol ≤5000ppm | 130ppm |
Impurity |
Impurity A A≤0.10% | ND |
 | Impurity B B≤0.10% | ND |
 | Impurity C C≤0.10% | ND |
 | Impurity D D≤0.10% | ND |
 | Impurity E E≤0.10% | ND |
 | Impurity F F≤0.10% | ND |
 | Individual impurity ≤0.10% | ND |
 | Total impurities ≤0.20% | ND |
Microbial limit test |
aerobic bacteria≤1000CFU/g | <10CFU/g |
 | fungus≤1000CFU/g | <10CFU/g |
 | Absence of escherichia coli | ND |
 Assay | 99.0~101.0%(anhydrous substance) | 100.0% |
Conclusion | Complies to EP7.0 |
Antidepressant Related materialÂ
ParoxetineÂ
Sertraline
Fluvoxamine maleate,
Citalopram hydrobromide,
Duloxetine hydrochloride,
Venlafaxine hydrochloride   Â
Duloxetine
Bupropion
Trazodone
Nefazodone
Mirtazapine
Moclobemide
Escitalopram
Gabapentin hydrochloride Mirtazapine
Quick Detail:Â
Product Name: Mirtazapine
CAS NO.: 85650-52-8
Molecular Formula: C17H19N3
Molecular Weight: 265.35
Purity: 99%
Appearance: White Powder
Grade: Pharmaceutical Grade
Description:
Mirtazapine, is an atypical antidepressant with noradrenergic and specific serotonergic activity. It blocks the α2 adrenergic auto- and heteroreceptors (enhancing norepinephrine release), and selectively antagonizes the 5-HT2 serotonin receptors in the central and peripheral nervous system. It also enhances serotonin neurotransmission at the 5-HT1 receptor and blocks the histaminergic (H1) and muscarinic receptors. Mirtazapine is not a serotonin or norepinephrine reuptake inhibitor but may increase serotonin and norepinephrine by other mechanisms of action.
Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA),and is used primarily in the treatment of depression. It is also commonly used as an anxiolytic, hypnotic, antiemetic and appetite stimulant. In structure, mirtazapine can also be classified as a tetracyclic antidepressant (TeCA) and is the 6-aza analogue of mianserin.It is also racemic - occurs as a combination of both (R)-(−)- and (S)-(+)-stereoisomers, both of which are active.
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Dosage:
Oral, can swallow with water, do not chew. The initial dose of adult treatment is 15mg (1/2 tablet) once daily, and then gradually increase the dose for optimal efficacy. The effective oral dose is usually 15-45mg (1/2 tablet-1.5 tablet) per day. Patients with liver and kidney damage, mirtazapine clearance decreased, so these patients medication should be noted. The half-life of mirtazapine is 20-40 hours, so medication can be done once a day, before going to bed to take effect better. Can also be sub-service, sooner or later each time. Patients should continue to take medicine, preferably in the symptoms disappear completely 4-6 months after withdrawal. Appropriate doses within 2-4 weeks will have a significant effect. If the effect is not obvious, the dose can be increased until the maximum dose, such as 2-4 weeks after the dose was still no significant effect, should immediately stop the medication .
COA:
Items | Standard | Â Â Â Result |
    Appearance | White or off-white powder | Complies |
Identification |
The IR absorption spectrum is accordant with the spectrum obtained with CRS |
Complies |
 Solubility | , Practically insoluble in water,freely soluble in anhydrous ethanol |
Complies |
specific rotation |
-0.10°~+0.10° (anhydrous substance) |
+0.001° |
Water | ≤3.5% | 2.8% |
Sulfated ash | ≤0.10% | 0.04% |
granularity | 80%<75 m | 39.28 m |
Residual solvents | Ethanol ≤5000ppm | 130ppm |
Impurity |
Impurity A A≤0.10% | ND |
 | Impurity B B≤0.10% | ND |
 | Impurity C C≤0.10% | ND |
 | Impurity D D≤0.10% | ND |
 | Impurity E E≤0.10% | ND |
 | Impurity F F≤0.10% | ND |
 | Individual impurity ≤0.10% | ND |
 | Total impurities ≤0.20% | ND |
Microbial limit test |
aerobic bacteria≤1000CFU/g | <10CFU/g |
 | fungus≤1000CFU/g | <10CFU/g |
 | Absence of escherichia coli | ND |
 Assay | 99.0~101.0%(anhydrous substance) | 100.0% |
Conclusion | Complies to EP7.0 |
Antidepressant Related materialÂ
ParoxetineÂ
Sertraline
Fluvoxamine maleate,
Citalopram hydrobromide,
Duloxetine hydrochloride,
Venlafaxine hydrochloride   Â
Duloxetine
Bupropion
Trazodone
Nefazodone
Mirtazapine
Moclobemide
Escitalopram
Gabapentin hydrochloride
Special grade black wolfberry usually refers to the size of the particle in 0.5-0.6 cm, is a better quality black wolfberry, the normal size of the black wolfberry, high anthocyanin content, generally described as the size of the soya bean.
Chaidamu black wolfberry grows in the basin desert area of 2800 meters -3000 meters above sea level, with high altitude and arid climate, clean ecological environment and no pollution. It was determined that Lycium ruthenium contained 17 kinds of amino acids and 13 trace elements, and the contents of calcium, magnesium, copper, zinc and iron were higher than those of Lycium barbarum.
Beauty and beauty, improve skin: prevent premature wrinkles and make skin younger and more vigorous. It not only prevents premature skin wrinkles, but also supplements nutrients and eliminates harmful free radicals in the body. Anthocyanins are natural sunshine covers that prevent ultraviolet radiation from the skin. If anthocyanins are used to protect the skin, about 85% of the skin cells can survive.
The analysis and determination of the protein amino acids, free amino acids, inorganic elements, vitamin C, B1, B2 and the total sugar and total acid in the fruit of the fruit of black fruit Lycium barbarum showed that the total sugar content in the fruit of black fruit Lycium was 6.9 and the total acid content was 0.735. It contains 18 kinds of essential amino acids, including asparagine, glutamic acid, alanine and proline, and most of them are free. The free amino acids accounted for about 50% of the total amino acid. The content of these amino acids exceeded the red wolfberry, and the content of Vc and fat was much higher than that of the red wolfberry, which was beneficial to the direct absorption of the human body. At the same time, the trace elements of the fruit are also rich, in addition to the constant elements Na, K, Mg, Ca, Fe, it also contains a certain amount of trace elements Mn, Sr, Se, Zn, Cr, Cu and so on. The trace elements have direct or indirect effects on the activity of various enzymes, the synthesis of nucleic acid and protein, the immunity of the body and cell proliferation, and can be used in cancer prevention and treatment. The content of vitamin C in the pulp of Lycium ruthenium is abundant, which can be used to supplement the deficiency of vitamin C in human body.
Black Wolfberry 0.5 Specifications
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