Business Club News, January 21
The current abuse of infusion is related to improper use of drugs, drug development, and public health knowledge. Injection itself is a risky method of administration. The main dangers are:
Injectable particles can cause acute death
Injectable microparticles are different from foreign substances and precipitates that are visible in the drug solution. They are insoluble impurities that are invisible to the naked eye.
Injectable microparticles can not be metabolized in the body and can cause granuloma, pulmonary edema, phlebitis, thrombosis, tissue necrosis, allergies, pyrogens and tumor-like reactions. Too much microparticles can cause acute death. However, due to the fact that particles are not in the visual range, their existence and harm are often overlooked.
In order to ensure the safety of medication, the pharmacopoeias of various countries have strictly limited the number and size of injectable microparticles. However, insoluble particles are affected by the type of drug, storage conditions, solvents, and methods of use. When multiple injections of drugs are combined, the microparticles are superposed and adsorbed to each other, increasing the number and making the particle size larger.
It is better not to lose traditional Chinese medicine to prevent cardiovascular disease
The elderly in the country are accustomed to adding traditional Chinese medicine injections such as Salvia miltiorrhiza to intravenous infusions in autumn and winter. It is said that there are effects of clearing blood vessels and reducing blood viscosity. This method is worth discussing.
The first problem is that the problem of excessive particulate matter in TCM injections is unsafe for long-term use. Traditional Chinese medicine injections produced by water decoction and alcohol precipitation method are complex in composition, unstable in quality, and sensitized macromolecules such as trace proteins and polysaccharides are difficult to eradicate, resulting in more common adverse reactions. For example, the appearance of Houttuynia injection is clear and colorless, giving the impression that the components are single and stable in nature, but actually more than 40 components that belong to different chemical structures can be detected. These components can form insoluble particles by oxidation and polymerization. Compound Salvia miltiorrhiza injection is not only of complex composition, but also the number of microparticles after dilution with glucose infusion is significantly increased.
Second, Chinese medicine injections are subject to stringent clarity and stability requirements. The content of active ingredients is limited. They should be used for emergency and non-oral use. The content of active ingredients is the material basis for prevention and treatment of disease. Traditional Chinese medicine is safe and convenient for preventing diseases, and due to the content of complete active ingredients, it is more effective than traditional Chinese medicine injection.
Multi-drugs use the same bottle to increase the risk of allergies
Another problem caused by the abuse of infusions is the use of multiple drugs in the same bottle. Penicillin, cephalosporins, and β-lactam drugs are mixed with other drugs, increasing the risk of allergies. Among them, the incidence of β-lactam drug hypersensitivity is closely related to the contained micro-organisms, in particular, it should not be used in the same bottle as the Chinese medicine injection that can easily exceed the standard.
Elderly, poor heart function, less infusion
In the elderly and those with poor cardiac function, excessive infusion can increase the burden on the heart. Giving the patient a small increase in heart load may also cause a butterfly effect, which may be a cause of worsening heart disease. Recently, the European Union has eliminated rosiglitazone, a well-established therapeutic drug for diabetes, with the focus on the fact that sodium salicylate caused by the drug can aggravate the burden on the heart and lead to an increase in cardiovascular events. This advanced concept is worth learning from.
The current abuse of infusion is related to improper use of drugs, drug development, and public health knowledge. Injection itself is a risky method of administration. The main dangers are:
Injectable particles can cause acute death
Injectable microparticles are different from foreign substances and precipitates that are visible in the drug solution. They are insoluble impurities that are invisible to the naked eye.
Injectable microparticles can not be metabolized in the body and can cause granuloma, pulmonary edema, phlebitis, thrombosis, tissue necrosis, allergies, pyrogens and tumor-like reactions. Too much microparticles can cause acute death. However, due to the fact that particles are not in the visual range, their existence and harm are often overlooked.
In order to ensure the safety of medication, the pharmacopoeias of various countries have strictly limited the number and size of injectable microparticles. However, insoluble particles are affected by the type of drug, storage conditions, solvents, and methods of use. When multiple injections of drugs are combined, the microparticles are superposed and adsorbed to each other, increasing the number and making the particle size larger.
It is better not to lose traditional Chinese medicine to prevent cardiovascular disease
The elderly in the country are accustomed to adding traditional Chinese medicine injections such as Salvia miltiorrhiza to intravenous infusions in autumn and winter. It is said that there are effects of clearing blood vessels and reducing blood viscosity. This method is worth discussing.
The first problem is that the problem of excessive particulate matter in TCM injections is unsafe for long-term use. Traditional Chinese medicine injections produced by water decoction and alcohol precipitation method are complex in composition, unstable in quality, and sensitized macromolecules such as trace proteins and polysaccharides are difficult to eradicate, resulting in more common adverse reactions. For example, the appearance of Houttuynia injection is clear and colorless, giving the impression that the components are single and stable in nature, but actually more than 40 components that belong to different chemical structures can be detected. These components can form insoluble particles by oxidation and polymerization. Compound Salvia miltiorrhiza injection is not only of complex composition, but also the number of microparticles after dilution with glucose infusion is significantly increased.
Second, Chinese medicine injections are subject to stringent clarity and stability requirements. The content of active ingredients is limited. They should be used for emergency and non-oral use. The content of active ingredients is the material basis for prevention and treatment of disease. Traditional Chinese medicine is safe and convenient for preventing diseases, and due to the content of complete active ingredients, it is more effective than traditional Chinese medicine injection.
Multi-drugs use the same bottle to increase the risk of allergies
Another problem caused by the abuse of infusions is the use of multiple drugs in the same bottle. Penicillin, cephalosporins, and β-lactam drugs are mixed with other drugs, increasing the risk of allergies. Among them, the incidence of β-lactam drug hypersensitivity is closely related to the contained micro-organisms, in particular, it should not be used in the same bottle as the Chinese medicine injection that can easily exceed the standard.
Elderly, poor heart function, less infusion
In the elderly and those with poor cardiac function, excessive infusion can increase the burden on the heart. Giving the patient a small increase in heart load may also cause a butterfly effect, which may be a cause of worsening heart disease. Recently, the European Union has eliminated rosiglitazone, a well-established therapeutic drug for diabetes, with the focus on the fact that sodium salicylate caused by the drug can aggravate the burden on the heart and lead to an increase in cardiovascular events. This advanced concept is worth learning from.
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