The combination of healthy eggs and sperm, normal uterus and fallopian tubes, proper biochemical environment and endocrine balance are all conditions for conception and maintenance of pregnancy. Abnormalities in any one of these factors may lead to miscarriage. Abortion will not only bring physical harm to patients, but will also bring a spiritual blow to the family. Abortion occurs three or more times in a row, and is medically known as habitual abortion. Habitual abortion is only a symptom, but behind this manifestation, the root causes of the disease are hidden. The most common causes are the following:
Genetic factors: Marriage between close relatives, abnormal chromosomes, or both of the husband and wife. The closer the blood relationship between the husband and the wife, the more likely the next-generation chromosomal abnormality is to become dominant. Chromosomal abnormal embryos can't survive and lead to miscarriage. Some also have teratogenic and fetal development. Delayed or, although alive, manifested as a dominant inheritance of chromosomal abnormalities.
Abnormal uterus development: congenital uterine malformations such as double uterine horn, saddle uterus, uterus is too small, intrauterine adhesions, uterine fibroids, etc. can also cause habitual abortion. The uterus is the place for implantation, growth, and growth of the embryo. It is the soil in which the embryo develops. Abnormal uterus prevents the normal development of the egg and leads to miscarriage. Therefore, it should be actively treated. Uterine dysplasia, uterine hypophysis can be used estrogen therapy, commonly used diethylstilbestrol 0.5mg ~ 1mg, 1 day, oral bedtime, since the 5th day of the menstrual cycle for 20 days, a total of 3 to 4 cycles; can also be foreign body stimulation Methods, such as intrauterine placement of a small IUD, to promote uterine enlargement; sometimes need surgery, such as removal of intrauterine adhesions, uterine plastic surgery, fibroids removal surgery.
Luteal insufficiency: Ovary rupture after ovulation, the formation of the corpus luteum, the corpus luteum secretion of progesterone and estrogen. After conception, the corpus luteum continues to degenerate after 4 to 6 months of pregnancy. The lifespan and function of the corpus luteum in early pregnancy are affected by human chorionic gonadotropin (HCG). After the uterus is implanted in the uterus, the trophoblasts are differentiated from the embryonic blastocyst cells. The uterine decidum that comes into contact with them will develop into the placenta in the future. The trophoblast will quickly secrete the HCG into the mother's body, prolonging the lifespan of the corpora lutea, and stimulating it. Synthetic progesterone to maintain pregnancy.
Maternal and child blood group incompatibility: The most common ABO blood type incompatibility, rare RH type, MN system blood type incompatibility. If the blood type between the mother and the fetus is not matched, the antigen the fetus has obtained from the father will enter the mother to produce antibodies. The antibodies will enter the fetal blood circulation through the placenta and act on the red blood cells to destroy the hemolysis, which can severely cause fetal death and lead to late abortion. In ABO blood group incompatibility, most pregnant women are type O blood, and the husband is type A, type B, or type AB blood. If the fetal blood type is type A or type B, late abortion may occur, but the incidence of such cases is not high.
Intracervical mouth relaxation: habitual late abortion is often caused by cervical intraoral relaxation. Due to surgical injury, a small number of congenital dysplasia caused by cervical intraoral expansion, while the uterine isthmus defects, after the middle of pregnancy, amniotic fluid increased, the fetus grew up, intrauterine pressure increased, fetal cysts from the cervix, prominent mouth, cervical tube gradually Shortening, expansion, when the pressure increases to a certain extent, the sudden rupture of the fetal membranes, leading to fetal discharge abortion. This repeated abortion can be based on the period of the previous abortion, choose to be in the 12 to 20 weeks of gestation line intrauterine suture, postoperative fetal tuberculosis treatment, to the full term pregnancy pregnancy abortion or scheduled cesarean section Remove the suture.
The causes of habitual abortion are more complicated. Only by finding out the reasons, targeted treatment can achieve satisfactory results. Women suffering from this disease should go to the hospital to do a comprehensive and systematic examination. After a miscarriage, especially women with ovarian dysfunction and uterine hypoplasia, it is best to undergo 3 normal menstrual cycles before conceiving, so that there is enough time to restore hormones and endometrial function.
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