Central pain management pathway found
June 05, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Why do some people have pains to deal with injections, and some people are painful? The reporter learned from Xi'an Jiaotong University on the 4th that the researchers of the Center for Neurology and Disease Research of the Institute of Frontier Science and Technology of the school recently confirmed for the first time that there is a direct projection of the sensory regulation of the cortex to the spinal cord and participates in the enhancement effect of spinal pain information. At the same time, this effect is not directly related to the brainstem pain regulation system. The research paper was published in the latest issue of Nature Newsletter.
Researchers at Xi'an Jiaotong University have discovered the direct projection of anterior cingulate gyrus (ACC) to the spinal cord through comprehensive utilization of whole-cell patch clamp recording, morphological tracking, immunoelectron microscopy and optogenetic techniques, and directly enhance the excitability of the spinal cord. Feel the message. ACC may be mediated to the spinal cord by direct projection to the spinal cord or transcerebral stem, which facilitates the down-regulation of sensory information transmission in the central nervous system. Sensory information is transmitted from the peripheral nerve sensory terminals to the spinal cord, and further transmitted to the sensory cortex. . The motor information is derived from the motor cortex and is transmitted directly to the spinal cord. Previous studies have not found that the sensory cortex has a direct projection of the spinal cord. ACC is part of the limbic system and is a nuclear group closely related to sensory and related emotional and cognitive functions. This study is of great significance for the pain regulation system in the brain. It provides a new idea for the sensory cortex to regulate the activity of spinal cord neurons. It is an important supplement to the previous brainstem-spinal regulation, especially the downstream regulation.
Professor Zhuo Min, director of the Center for Neurological and Disease Research at Xi'an Jiaotong University, said that the excitability of ACC is increasing in the case of chronic pain, and this increase plays a very important role in the maintenance of chronic pain. If these excitability are reduced by genetic and pharmacological approaches, analgesia can be produced. The increased excitability of ACC leads to an increase in the transmission of spinal cord pain signals. Patients with ailments are more sensitive to pain, not only on the brain, but also on the spinal cord. The in-depth advancement of this research is of great significance for the design of new treatments and new drugs to control the chronic pain of patients in the future. (Reporter Shi Junbin)
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