According to the Science and Technology Daily, he was only sad for 30 seconds after the exhibition with the Nobel Prize. He was not sad after 1 minute. He is more willing to talk about cancer immunotherapy.
In 1999, B7-H1 (also known as PD-L1) molecules were found on the surface of tumor cells, and this molecule was later found to bind PD-1. He subsequently invented the use of antibodies to block this immunosuppressive pathway, pushing anti-PD-1/PD-L1 antibodies into clinical trials.
In the speech of the 2018 World Life Science Conference, Display Ping introduced that past cancer immunotherapy attempts to inhibit tumor growth by enhancing the patient's immune response, and the latest idea is to normalize the immune response.
"Because the immune response of the patient is eliminated during the tumor growth process, it is more efficient and less toxic to find a way to restore the immune response to normal levels. This is also the treatment of cancer with PD-1 or PD-L1 antibody drugs. The main idea. Cancer immunotherapy may have a greater breakthrough in the next few years, although there are still many mechanisms for cancer immunotherapy to be clear, but the general direction is more and more clear, and more and more people are studying, the speed of progress Will speed up." Display Ping said.
Since the fire of PD-1 or PD-L1, many people have begun to improve related therapies. However, the focus of display has shifted to the new question: Why are some patients using PD-1 or PD-L1 antibody drugs ineffective? What is the reason for invalidity? Can you find a way to treat such patients?
Display Ping believes that originality is the basic requirement for doing research. "It is relatively easy to be able to add icing on the basis of others. What is really difficult is to open up new fields and solve problems that others cannot solve. When the foundation is weak, you can do some tracking work, but when you have certain strength, It’s time to start doing things that others can’t do or don’t dare to think about.†Display Ping said.
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