In terms of appearance, the three transgenic pigs cultivated by Hubei Academy of Agricultural Sciences are similar to ordinary pigs. However, such pigs carry human genes. The serum human albumin content in pigs increases by 20.3 g and can be extracted from the pigs. For clinical human serum albumin.
Human serum albumin is the main component in human plasma and is mainly used clinically to treat shock and edema caused by blood loss, trauma, and cancer. At present, medical albumin is extracted from human blood, but the limited blood resources limit the production and use of albumin. It is claimed that since 1990, albumin demand has risen by 49.2% annually in China's 50 best-selling drugs.
The use of transgenic animals for the production of medical albumin is a cutting-edge topic in the field of international biotechnology research today. The genetically modified research group led by Wei Qingxin, a researcher at the Hubei Academy of Agricultural Sciences, applied molecular biotechnology to reconstitute the human serum albumin fusion gene that can be expressed in pig livers and inject it into a diameter of 150 using a 10 micron microinjection needle. In the fertilized eggs of micron-sized and round-shaped pigs, this genetically modified pig was selected and bred.
According to the "Hubei Daily" report, the hospital has been leading the research field of transgenic pigs since it took the lead in undertaking the national "863" project of "lean breed pig genetic engineering breeding" in 1988. At present, the results of this study are still a long way from industrialization. The next step will be to focus on solving the problem of separation and purification of albumin so that it can enter mass production as soon as possible and establish a “drug factory†with transgenic pigs as its carrier.
Human serum albumin is the main component in human plasma and is mainly used clinically to treat shock and edema caused by blood loss, trauma, and cancer. At present, medical albumin is extracted from human blood, but the limited blood resources limit the production and use of albumin. It is claimed that since 1990, albumin demand has risen by 49.2% annually in China's 50 best-selling drugs.
The use of transgenic animals for the production of medical albumin is a cutting-edge topic in the field of international biotechnology research today. The genetically modified research group led by Wei Qingxin, a researcher at the Hubei Academy of Agricultural Sciences, applied molecular biotechnology to reconstitute the human serum albumin fusion gene that can be expressed in pig livers and inject it into a diameter of 150 using a 10 micron microinjection needle. In the fertilized eggs of micron-sized and round-shaped pigs, this genetically modified pig was selected and bred.
According to the "Hubei Daily" report, the hospital has been leading the research field of transgenic pigs since it took the lead in undertaking the national "863" project of "lean breed pig genetic engineering breeding" in 1988. At present, the results of this study are still a long way from industrialization. The next step will be to focus on solving the problem of separation and purification of albumin so that it can enter mass production as soon as possible and establish a “drug factory†with transgenic pigs as its carrier.
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