Longevity 10 years of genes, a breakthrough breakthrough found, summit "science Everest"!
If Qin Shihuang is still alive, he will hear the reliable news of this "longevity gene". Maybe he will not "make a big move" and send people to find the immortal "Xiandan". Chinese history may be rewritten...
On June 16th, Science Advances, a well-known international journal of the "World Science Everest", published "Science Advances", which published heavy evidence on "longevity genes": in different ethnic Americans, French and German In the Ashkenazi Jews group, males with mutations in the d3-GHR gene can live an average of 10 years and a height of 1 inch compared to males with negative mutations!
In this way, the genetic renewal is really "iron-proof", it is not a myth!
Everyone is so excited, it is entirely because of this longevity gene state - d3-GHR, English full name: growth hormone receptor exon 3 deletion, Chinese name: growth hormone receptor gene exon 3 deletion mutation.
In fact, behind d3-GHR involves a series of “biological signals†related to “life and death†– such as the GH/IGF signal axis (GH: growth hormone; IGF: insulin-like growth factor), which has gained more and more evidence. It may be involved in regulating many life activities of the human body, such as energy metabolism, immunity, inflammation, growth and development, and aging.
In the activation switch of these activity signals, growth hormone (GH) binds to the growth hormone receptor (GHR) on various types of cells, which is a key link. However, the GHR gene exhibits a polymorphism that varies from person to person—for example, the d3-GHR mutation in the gene, some people have, some do not, and some are heterozygous mutations (the father or mother unilaterally mutated the gene) The mutation is not complete. Some people are homozygous mutations (the genes from both parents are mutated and the mutations are thorough enough), which can also explain: for different people's life activities and even disease manifestations, it is also very different.
Scientists from France, the United States, and Israel have joined forces to study the effects of d3-GHR mutations on human life. They have analyzed and analyzed the cohort of 4 people: (1) 567 Ashkenazi Jews elderly and their offspring cohorts (aged over 60 years old, including centenarians); (2) American Amish elderly cohort (the Old Order Amish, 152 men); (3) American Cardiovascular Health Study (61 men); (4) French Long-Lived Study (61 men) ).
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