Singapore developed a dual-axis rotary bioreactor

Release date: 2009-01-07

Recently, Singapore Polytechnic Institute successfully developed the world's first dual-axis rotary bioreactor, which can use the patient's own stem cells to “tailor-made” new bones, and then the doctor placed it on the fracture of the bone to make the stem cells slowly differentiate. Osteoblasts, fused with bone cells surrounding the fissure, repair broken bones. This technique has been successfully tested on the rat leg bones, and the mice that have been removed from the leg bones can be cured within 3 months. Zhuang Wensheng, the principal researcher of the technology, said that the next experiment should be done with several larger animals before clinical trials can be conducted on humans.

According to the researchers, they used the ruptured skull to test the honeycomb tissue scaffold according to the shape and thickness of the cranial incision, and then used the stem cells extracted from the patient's bone marrow as “seeds” and placed them in the reactor vessel. Add red nutrient liquids to the container, including glucose, vitamins and amino acids. Stem cells need these nutrients to “reproduce”. After the reactor is started, the container rotates according to the set computer program according to the vertical and horizontal axes, allowing the stem cells to "breed" with the liquid flow and "live" into the stent. When the honeycomb tissue scaffold "fills" the stem cells, the stent can be removed from the container and secured to the indentation of the skull. After a few days, the stem cells in the scaffold will be differentiated into bone cells by the influence of surrounding bone cells, and the scaffold can also decompose by itself. In addition to repairing the skull, this technique is also suitable for thicker bone repairs such as the eyelids, the lower jawbone and the leg bones.

Bioreactors use the biological functions of enzymes or organisms (such as microorganisms) to create an environment similar to that in the body and accelerate the system of culturing cells, tissues and even organs. It is a biological function simulator, such as a fermenter, an immobilized enzyme or an immobilized cell reactor. Previous bioreactors were only able to rotate uniaxially, and the reactor developed by Singapore Polytechnic was biaxially rotating, using computational fluid dynamics to allow nutrients to flow through the liquid and distribute them more evenly into stem cells. This method of cultivating stem cells is ten times faster than that cultivated in a culture dish, which greatly shortens the treatment time, which is particularly useful in cases where the area of ​​bone damage is particularly large.
——Shanghai Medical Device Industry Association


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