1 Incidence
In September 2005, a farmer in the southern suburbs of Shangqiu City purchased 15 piglets of 60 days old from outside pig dealers. On the 3rd day, he developed sporadic fever, asthma, anorexia, lack of energy, and lying and lying. After treatment with antibiotics, it improved slightly but relapsed after discontinuation. Five of the sick pigs died due to ineffective medication. Soon, 12 fattening pigs raised by the farmer had also developed diseases. They had used antibiotics, red bows, and hot acupuncture needles to treat them. The effect was not obvious. Two of the pigs developed systemic jaundice, and red feces and urine appeared. They quickly died of weight loss and died. According to surveys, four pig farmers in the same village have also experienced similar situations with the farmers. The incidence rate was 11.2%, and the mortality rate was 50% to 70%.
2 clinical symptoms
2.1 The body temperature of piglets rises to about 40°C. The conjunctiva and skin are pale. Some of the piglets had reddish-purple skin behind the ears, inside the limbs, and under the abdomen. There were bleeding spots and bleeding spots. The pigs developed asthma and discharged yellow sticky odor and faeces. The disease duration was about 2 weeks, and the mortality rate was higher than that of fattening pigs.
2.2 The fattening pigs mainly exhibit high fever, loss of appetite, depression, and lying and lying down. 3 to 5 days after the onset of disease, part of the pig's skin was light red, part of the pig's skin was pale, part of the pig's ears behind the abdomen and limbs inside the skin cyanotic and bleeding spots or bleeding spots. After treatment with antibiotics and antiviral drugs, the condition was slightly relieved but relapsed after discontinuation and excreted sauce red urine.
3 necropsy changes
3.1 The piglets are mainly of coronary fat, auricular hemorrhage; soft and weak heart muscle; hydrothorax in the pleural cavity, meaty changes in the lungs, emphysema in some parts; hepatomegaly, black, white necrotic spots; splenomegaly, blood stasis, Bleeding points, similar to the wedge-shaped infarct around; kidney filled with bleeding, after the cut can be seen in the tubular full of urate; intestinal congestion bleeding; lymphadenopathy hemorrhage, peripheral bleeding, some marbled.
3.2 The fattening pigs mainly have different degrees of bleeding in all body organs. Systemic lymphadenopathy was purple, peripheral bleeding or marble-like section; throat with mucus and a small amount of bleeding; bleeding at the bottom of the stomach, intestinal bleeding, intestinal wall thickening, mucosal hyperemia, hemorrhage, ileum end, There were typical button-like necrosis and ulcer changes in the cecum and colon mucosa; the bladder walls were bleeding and filled with a lot of red sauce urine and a lot of crystallization.
4 Laboratory inspection
4.1 Microscopically inspected by direct microscopic examination of fevery pig ear vein blood smears, it can be seen that the shape of red blood cells is irregular, some red blood cells are star-shaped, and some red blood cells are serrated. There are 2 to 3 or 3 to 5 deformed erythrocyte surfaces, and even more than 10 erythroid bodies with different shapes. Some of the erythroid bodies are spherical, some are ovoid or comma-shaped. Some erythroid bodies are also free from plasma. In mild cases, normal red blood cells and deformed red blood cells can be seen at the same time, and normal red blood cells can hardly be seen in severe cases.
4.2 Detection of hog cholera antigens Frozen sections of the tonsils, spleens, and ileum of diseased pigs were harvested and subjected to a direct fluorescent antibody (FA) test. As a result, the hog cholera virus antigen was positive. In order to distinguish between swine fever virus and mucosal disease virus, an ELISA test was conducted. As a result, the swine fever virus antigen was still positive, and it was a attenuated vaccine.
5 Diagnosis
According to clinical symptoms, necropsy changes and laboratory tests, the diagnosis was confirmed as a mixed infection of pig Eperythrozoon and swine fever.
6 Prevention measures
Strengthen feeding and management, do a good job in environmental disinfection, replace the bred material with pig feed, and add appropriate amount of electrolysis in feed to increase resistance.
With clear decoction and detoxification, detoxification, blood circulation, cooling blood to save yin. Formula: Gypsum 24 g, Rehmanniae 6 g, Buffalo horn 12 g, Coptis chinensis 5 g, Gardenia 6 g, Cortex Moutan 5 g, Radix Astragali 5 g, Radix paeoniae Rubra 5 g, Scrophulariaceae 5 g, Anemarrhena 6 g, Lian Alice 6 grams, 5 grams of Campanulaceae, 3 grams of licorice, 5 grams of light bamboo. Decoction, 1 dose per day, 3 to 5 doses. For emergency vaccination of single swine fever vaccine, use long-acting oxytetracycline or blood net deep intramuscular injection. For a single dose of piglet to use 10 times the dose, long-acting oxytetracycline should be used continuously for 3 to 5 days or blood worm net at 5mg/kg, diluted to a concentration of 5% deep intramuscular injection. For pigs that have high fever and no visible red urine, daily calculations are based on 100 kg of body weight. In the morning, a new sensory clearance 15g, a potent amosen, and a net bloodworm net (first two) are applied. Oxytetracycline 2ml, continuous medication for 3 days. For high-calorie pigs with sauce red urine, daily infusion, calculated on a per pig basis, sugar water 50 ml, a potent amosen, a dexamethasone 2, vitamin C 10 ml, adenosine triphosphate 2, coenzyme A2, top 3 Day with the application of sodium bicarbonate 50ml, continuous medication for 5 days.
7 Summary
Using the above-mentioned prevention and control measures, the condition has been controlled after 3 days, and the diseased pig recovered after 5 days.
At present, there is no specific treatment for swine fever, while erythrozoonosis can be treated with oxytetracycline and other drugs. Therefore, the key to the prevention and treatment of mixed infections of swine fever and Eperythrozoon is the emergency vaccination of swine fever vaccine to control swine fever, and the use of Chinese herbal medicine for symptomatic treatment and the use of appropriate drugs for the treatment of Eperythrozoonosis.
The occurrence of Eperythrozoonosis in swine pigs with swine fever was probably due to insufficient attention paid by the grass-roots to swine fever. The immunization procedure and dose of swine fever must be in place. When piglets are vaccinated against swine fever, the effects of maternal antibodies and the quality of the vaccine must be taken into account. To prevent the interference of maternal antibodies, swine fever is now available in large swine farms. In 4-6 heads.
It is necessary to diagnose the disease as soon as possible, and do not use drugs blindly, so as not to delay the timing of treatment and bring greater economic losses to farmers.
Medicine Cabinet,Hospital Medicine Cabinet,Detachable Medicine Cabinet,Practical Medicine Cabinet
NANJING TIANAO MEDICAL INSTRUMENTS MANUFACTURE CO.,LTD. , https://www.tianaomedical.com