Cases of human infection with H7N9 avian influenza, first discovered in China earlier this year, have caused widespread concern. Chinese and foreign researchers have recently discovered that the H7N9 virus is likely to be produced by genetic recombination in different chickens in different chickens, and the resulting "by-product" is the previously unknown H7N7 virus.
Researchers from the University of Hong Kong and their counterparts in the United States and Canada reported the findings in a new online edition of Nature on the 21st. The researchers collected samples from the oropharynx and digestive tract of poultry and wild birds such as chickens, ducks, and geese, and performed genome-wide sequencing of the viruses isolated from them to confirm the source of each gene component in the H7N9 virus and the virus. The path of evolution in various birds.
Zhu Huachen, a researcher at the University of Hong Kong, one of the leaders of the study, said that the analysis showed that the ducks first transmitted similar viruses from wild birds. The virus was initially reconstituted in domestic ducks and then transmitted to chickens. The H9N2 virus was genetically recombined like shuffling, and eventually the H7N9 virus was produced in chickens.
Studies have shown that H7N9 virus is mainly found in the oropharynx and respiratory tract of chickens, and is likely to be transmitted from these parts to humans. The researchers said the findings reveal the origin and mode of transmission of the H7N9 virus, helping to cut off the chain of transmission and prevent H7N9 outbreaks.
The study also found that the previously unknown H7N7 virus was also produced during the genetic recombination of the H7N9 virus. Animal experiments have shown that the H7N7 virus has an infection and pathogenic ability to ferrets. The mechanism of ferrets in infecting respiratory viruses is similar to that of humans and is often used as an animal model for testing viruses. Researchers therefore believe that H7N7 is likely to have the ability to infect people and should be alert to its threats.
The researchers stressed that from the evolutionary path of H7N9 virus and H7N7 virus, domestic ducks and chickens will interact in the process of virus production and transmission, which means that different species are best in breeding, breeding, transportation and sales. Separated to avoid virus cross-species transmission and recombination to generate new viruses.
Researchers from the University of Hong Kong and their counterparts in the United States and Canada reported the findings in a new online edition of Nature on the 21st. The researchers collected samples from the oropharynx and digestive tract of poultry and wild birds such as chickens, ducks, and geese, and performed genome-wide sequencing of the viruses isolated from them to confirm the source of each gene component in the H7N9 virus and the virus. The path of evolution in various birds.
Zhu Huachen, a researcher at the University of Hong Kong, one of the leaders of the study, said that the analysis showed that the ducks first transmitted similar viruses from wild birds. The virus was initially reconstituted in domestic ducks and then transmitted to chickens. The H9N2 virus was genetically recombined like shuffling, and eventually the H7N9 virus was produced in chickens.
Studies have shown that H7N9 virus is mainly found in the oropharynx and respiratory tract of chickens, and is likely to be transmitted from these parts to humans. The researchers said the findings reveal the origin and mode of transmission of the H7N9 virus, helping to cut off the chain of transmission and prevent H7N9 outbreaks.
The study also found that the previously unknown H7N7 virus was also produced during the genetic recombination of the H7N9 virus. Animal experiments have shown that the H7N7 virus has an infection and pathogenic ability to ferrets. The mechanism of ferrets in infecting respiratory viruses is similar to that of humans and is often used as an animal model for testing viruses. Researchers therefore believe that H7N7 is likely to have the ability to infect people and should be alert to its threats.
The researchers stressed that from the evolutionary path of H7N9 virus and H7N7 virus, domestic ducks and chickens will interact in the process of virus production and transmission, which means that different species are best in breeding, breeding, transportation and sales. Separated to avoid virus cross-species transmission and recombination to generate new viruses.
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