Release date: 2010-08-16
Bioengineers at the University of California, San Diego, and GlySens have successfully developed an implantable glucose sensor and wireless telemetry system to continuously monitor tissue blood glucose and transmit information to an external receiver. . Related papers were published in the journal Science Translational Medicine (Journal of the medical Science) on July 28, 2010. The glucose detection device has been implanted in animals for more than a year. Diabetes patients currently use short-term, needle-shaped glucose sensors that need to pierce their fingers and must be replaced every 3 to 7 days. Once approved by human clinical trials and FDA approval, this long-used implantable glucose sensor will replace the glucose sensor currently used by diabetics.
David Gough, professor of bioengineering at the University of California, San Diego, said, "The most important point of this paper is that our glucose sensor is still non-irritating to the coated tissue in the case of implantation (in animals) for more than 500 days. From a scientific point of view Look, this is a big improvement, thanks to the sensor's unique oxygen content detection program." David Gough is the first author of this paper published in the journal Science Translational Medicine.
Glucose and oxygen from around the tissue diffuse to the sensor where the glucose oxidase reacts chemically, wherein the oxygen consumed is proportional to the amount of glucose. The remaining oxygen is measured and then compared to an oxygen reference recorded by an almost identical oxygen content reference sensor. The comparison of the oxygen reduction signal with the reference oxygen signal reflects the concentration of blood glucose. The effects of motion and changes in local blood flow to the tissue are largely removed by the differential oxygen sensing system, which places a pair of sensors in parallel in the same device. The glucose sensor, which was implanted in pigs, was 1.5 inches in diameter and 5/8 inches thick and could be implanted through a simple outpatient procedure.
(Source: Kexun)
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