Chinese and American scientists find that anti-Zika virus protein is expected to be used to suppress HIV

March 17, 2017 Source: China News Network

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On the 15th, the Institute of Systems Medicine of the Chinese Academy of Medical Sciences, Suzhou Institute of Systems Medicine ("System") published a study with the University of California, Los Angeles and other institutions. The researchers found that protein cholesterol-25-hydroxylase (CH25H) and its enzymatic reaction product, 25-hydroxycholesterol (25HC), have a clear protective effect against diseases caused by Zika virus infection and are expected to be used to suppress Ebola. Virus, HIV, etc. The results have been published in the internationally renowned journal Immunity.

Zika virus has erupted in Brazil and other countries in the world since 2015 and still threatens human health on a global scale. There have been dozens of imported Zika cases in China. Once a pregnant woman is infected with Zika virus, it may lead to abnormal fetal development, neonatal microcephaly and other neurological diseases. There are currently no effective therapies for Zika virus, and there are no vaccines that have passed clinical trials.

According to Dr. Li Chunfeng from the system involved in the research, as early as 2013, Chinese and American scientists discovered a broad-spectrum antiviral effect of 25-hydroxycholesterol. After the outbreak of Zika virus, the system responded to the national call, the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences, the Institute of Genetics of the Chinese Academy of Sciences and the University of California, Los Angeles, and other institutions to carry out joint research on the possibility of 25-hydroxycholesterol against Zika virus. research.

Cholesterol-25-hydroxylase is an interferon-stimulated gene whose gene expression product oxidizes cholesterol to produce 25-hydroxycholesterol. Through experiments, the researchers found that 25-hydroxycholesterol can directly block the process of virus entry into cells, and has broad-spectrum antiviral activity against a variety of arboviruses including Zika virus. Using a Zika virus-infected mouse model and a rhesus animal model, the researchers found that 25-hydroxycholesterol treatment significantly inhibited viral replication in the body and effectively prevented the development of microcephaly.

Professor Cheng Genhong, who is involved in the research, said that 25-hydroxycholesterol is the first small molecule found to inhibit Zika virus replication in monkeys, and the first to prevent Zika virus infection in mice. A compound of cephalitis. The outlook is considerable.

"In theory, it works equally well in the human body. Next we will begin clinical trials to verify the effectiveness of 25-hydroxycholesterol in the human body," Cheng Genhong said. The system will also study the antiviral effects of 25-hydroxycholesterol derivatives and find more effective substances that can inhibit Zika virus infection. Completely eliminate the threat of Zika virus to humans.

In addition, based on the broad-spectrum antiviral effect of 25-hydroxycholesterol, Chinese and American scientists have confirmed through experiments that 25-hydroxycholesterol can inhibit Ebola, HIV and so on. The two sides will continue to cooperate and apply them to the prevention and treatment of new and emerging viral infectious diseases, and provide new solutions for effective prevention and treatment of viral infectious diseases.

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