Release date: 2007-03-22
According to a report by the Australian Broadcasting Corporation on March 15th, a recent study suggests that bullying could negatively affect the survival of new brain cells and might even contribute to depression. Researchers discovered that when mice were subjected to bullying, they produced new nerve cells in areas of the brain responsible for memory and emotions. However, most of these newly formed cells eventually died, indicating that stress may be responsible for their death. This discovery could potentially lead to new treatments for depression.
Daniel Peterson, an associate professor at Roslinde Franklin University of Medical Sciences in Chicago, led the research. He stated, “If we can keep these new nerve cells alive, it might help prevent common cases of depression.†In the experiment, two older mice were placed with a younger one in the same cage for about 20 minutes. The older mice quickly chased the smaller mouse to a corner and pinned it down. The young mouse showed signs of fear and depression, and its stress hormone levels were six times higher than normal.
Based on previous findings, Peterson and his team initially believed that high levels of stress hormones would stop the growth of new nerve cells or kill them immediately. However, their microscopic analysis revealed that new cells had indeed been created. But within a week, only one-third of them survived. This unexpected result raised more questions about how stress affects brain cell development.
Peterson plans to further investigate how antidepressants might help save these nerve cells. However, he notes that most current antidepressants take weeks to work, so results from this research might not come quickly. “We see that stress can change the environment in the brain,†he said. “This is something we need to understand better, as it could guide us toward more effective treatments.â€
This study highlights the complex relationship between psychological stress and brain health, offering new insights into the biological mechanisms behind depression and potential future therapies.
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