Release date: 2007-08-02
A breakthrough in stent technology is on the horizon, with new coated stents expected to address a critical issue—stent thrombosis. SurModics (Nasdaq: SRDX) and Paragon have joined forces to develop an innovative coronary stent system that combines SurModics' FINALE Prohealing coating technology with Paragon's advanced thin-walled stent design. This collaboration aims to tackle one of the most serious complications associated with coronary stents.
According to interventional cardiologists, while stent thrombosis is relatively rare, it can be a life-threatening complication. The new stent system is designed to reduce this risk by promoting faster and more complete healing of the endothelial lining after implantation. SurModics' FINALE coating uses extracellular matrix (ECM) proteins, which help activate the body's natural healing processes, encouraging the regeneration of healthy blood vessel tissue.
This approach not only helps prevent new clot formation but also reduces the likelihood of restenosis, or re-narrowing of the artery. By integrating this biologic coating with Paragon's ultra-thin stent design, the resulting device offers the benefits of drug-eluting stents without the long-term risks typically associated with traditional coatings.
"We're excited to partner with Paragon and Apollo to bring this innovative solution to market," said Bruce Barclay, CEO of SurModics. "The preclinical data for our FINALE technology are very promising, and we believe this could significantly improve patient outcomes."
Dr. Williams, a leading expert in cardiovascular tissue engineering, has been working closely with SurModics to enhance the healing process through the use of ECM proteins. His research focuses on developing next-generation implantable devices that support the body’s own repair mechanisms. Together with the University of Arizona, SurModics conducted successful preclinical trials of the FINALE-coated stents.
Paragon’s technology allows for even thinner stent walls and smaller diameters, making them easier to deliver via catheter and more flexible during implantation. This advancement overcomes a common challenge in stent design, where stents often expand slightly during manufacturing, making them harder to handle. With the new material properties, the stents remain tightly closed until they reach the target site, ensuring better control and precision during the procedure.
This partnership represents a major step forward in the field of interventional cardiology, combining cutting-edge materials science, biological engineering, and clinical expertise to create a safer, more effective treatment option for patients with coronary artery disease.
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