Toll-like receptor signaling pathway map

The inflammatory response induced by members of the TLR family (except TLR3) goes through a classical signaling pathway (Fig. 1) that begins with an intracellular conserved sequence of TLRs—Toll/IL-1 receptor homology (Toll/IL) -1receptor homologousregion, TIR). TIR activates intracellular signaling mediators - IL-1R associated kinase (IRAK) IRAK-1 and IRAK-4, tumor necrosis factor receptor-associated factor 6 (TNFR-associated factor 6, TRAF- 6), mitogen activated protein kinase (MAPK) and IκB kinase (IκB kinase, IκK), and then activate nuclear factor κB (nuclear factor κB, NF-κB), induce the expression of inflammatory factors.
The signal molecules involved in this signal transduction mainly include:
CD14, MD-2, TRAM, TRIF, TIRAP, MyD88, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, IRAK-1, IRAK-2, IRAK-4, IRAK-M, TRAF6, TRIAD3A, ST2L, SOCS1, RIG-I, FADD, TOLLIP, RIP1, A20, UEV1A, Ubc13, ECSIT, MEKK-1, TAK1, TBK1, MKK3/6, p38, TAB1/2, MKK4/7, JNK, IKKα, IKKβ, IKKγ, IKKε, NEMO, IκBα, NF-κB, p65/RelA, Casp-8, IRF-3, IRF-7, MAVS, etc.
Click on the signal molecule in the figure to view detailed pathway maps and products (inhibitors, antibodies, phosphorylated antibodies, assay kits, recombinant proteins, etc.):

Long Range LiDAR Radar

Long distance LiDAR sensor IT03M series are particularly easy to communication thanks to their fixed connector, which can be plugged it up and off by yourself. Voltage is wider from 3.3v before to 3.6v. Low power consumption feature makes it beceome a very competitive, high performance-price ratio, long range Laser Distance Sensor.

Highlights:

> Measurement frequency: 100 Hz (Max 200 Hz)
> High temperatures: -10~+50℃
> UART output
> Connector design: easy to use

It03m Long Range Tof Sensor Module Diagram

Parameters of IT03M:

Accuracy

+/-5cm@ 0.1~2.5m

Measuring Unit

cm

Measuring Range (without Reflection)

0.1-15m

Measuring Time

0.1~3 seconds

Measuring Frequency

100 Hz

Laser Class

Class II

Laser Type

650nm, <1mw, red

Weight

About 10g

Voltage

DC2.5V~+3.5V

Serial Level

TTL 3.3V

Size

50*26*13mm

Operating Temperature

0-40 ℃ (32-104 ℉ )

Storage Temperature

-25~60 ℃ (-13~140 ℉)


Speed Laser Sensor,Long Range Lidar,Long Range 3D Lidar,Long Range Radar Sensor

Chengdu JRT Meter Technology Co., Ltd , https://www.jrt-measure.com

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